Dr. Zhe-Sheng (Jason) Chen received his M.D. degree from Guangdong Medical and Pharmaceutical College (now, named as Guangdong Pharmaceutical University), Master degree from Sun Yat-Sen University School of Public Health, China and Ph.D. degree from Kagoshima University Faculty of Medicine, Japan. He worked as a JSPS (Japanese Society for Promotion Science) fellow and then as a postdoctoral fellow in medical oncology at Fox Chase Cancer Center. After 4 years as an assistant professor and 4 years as an associate professor at St. John's University College of Pharmacy and Health Sciences, receiving tenure in 2010, and he was promoted to full professor in 2012. His interests range from laboratory studies and clinical studies on drug resistance in leukemia, ovarian cancer, lung cancer and others. The goal of the Cancer Pharmacology Laboratory is to develop more effective chemotherapeutic agents for cancer patients. Multidrug resistance (MDR) represents a major obstacle to the treatment of cancer, and understanding the resistance mechanisms and knowing how to reverse the resistance hold the promise of providing insights that may lead to improvements in the use of currently available anticancer drugs. The laboratory is dedicated to find anticancer agents that, alone, or in combination with other agents to circumvent drug resistance in cancer treatment. Chen’s laboratory is interested in the molecular and cellular pharmacology of anticancer drugs, such as drug resistance mechanisms and reversal of resistance study and new drug development. A promise of our research program is that progress in the chemotherapy of cancer will depend on rational combination of agents that reduce the function of plasma membrane transporters such as P-gp, ABCG2 and MRPs, and to enhance the actions of cytotoxic drugs. In collaboration with many researchers in USA, China, Japan, Canada, Australia and Egypt, studies in Chen’s laboratory focus on screening and identifying new inhibitors of ABC transporters by in vitro membrane vesicles transport assay system and cell based assay systems. Another research direction is to study the role of ABC transporters family on the detoxification of chemicals (including carcinogens and mutagens) using knock out mouse models. Dr. Chen is an Editor-In-Chief of Journal of Cancer Research Updates and Journal of New Developments in Chemistry; Editor of African Journal of Pharmacy and Pharmacology (AJPP); Regional Editor of Recent Patents on Anticancer Drug Discovery (RPADD); Guest Editor of Current Pharmaceutical Biotechnology, Cancers, and Journal of International Medical Research. Dr. Chen is also an Associate Editor of Journal of Analytical Oncology, and Journal of Cancer Metastasis and Treatment. He is also an editorial board member of 26 journals and a reviewer of more than 170 peer reviewed journals. As a consultant to pharmaceutical, biotechnology and health industry organizations, Dr. Chen commands invitations for more than 150 presentations, keynote addresses, and conference chairman. He published more than 170 publications in peer reviewed journals. He is also a grant reviewer of NIH, Chinese National Natural Science Foundation (China), The Genesis Oncology Trust (New Zealand), National Science Centre (Poland), The Government of the Hong Kong Special Administrative Region (HKSAR) Grant, Hong Kong (China), the Hungarian Scientific Research Fund (OTKA) (Hungary), the Netherlands Organisation for Scientific Research (NWO) (Netherlands), and the Czech Science Foundation (Czech) etc. Dr. Chen is also a director of Institute for Biotechnology and a member of University Global Coordinating Committee (UGCC) at St. John’s University.
Certifications, Honors, Awards, and Other Recognitions
Excellent Medical Student Prize, 1997, YASUDA Medical Research Foundation, Japan.
Young Investigators' award in 5th Hong Kong International Cancer Congress, 1998. China.
The Japan Research Foundation for Clinical Pharmacology Award (for overseas research), 2000, Japan.
Sixth Annual Postdoctoral Research Conference award, Fox Chase Cancer Center, 2001, USA.
AACR-Ortho Biothech, Inc. Scholar-In-Training award, the 94th Annual AACR Meeting, 2003, USA.
Faculty Recognition Award of St. John’s University for multiple years, USA.
Special Recognition Award of St. John’s University, 2011, USA.
Outstanding Achievement Award of St. John’s University, 2016, USA